A two-year, open-access project organized by more than 20 organizations, including Wellcome, in London, the Bill & Melinda Gates Foundation, in Seattle, and Dutch NOW—some of the world’s largest research funders—began requiring in January that scholarly papers published from the work they fund be made immediately available for public reading at no charge. The initiative, Plan S, may usher in the end of journal subscriptions and allow anyone to read scientific literature. Plan S has already prompted several titles, including Nature, to offer open-access publishing for the first time.